6533b857fe1ef96bd12b4386

RESEARCH PRODUCT

Statistical Approach for Biomarker Discovery Using Label-Free LC-MS Data: An Overview

Patrick DucoroyCaroline Truntzer

subject

ChromatographyLiquid chromatography–mass spectrometryChemistryBiomarker discoveryTandem mass spectrometryMass spectrometryWarping functionLabel free

description

The identification of new diagnostic, prognostic, or theranostics biomarkers is one of the main aims of clinical research. Technologies like mass spectrometry (MS) focus on the discovery of proteins as biomarkers and are commonly being used for this purpose. Mass spectrometry consists in the separation by gas of charged molecules, based on their mass-over-charge. Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) first involves a separation by liquid chromatography (LC) followed by mass spectrometry in the MS and MS/MS modes.

yearjournalcountryeditionlanguage
2016-12-16
https://doi.org/10.1007/978-3-319-45809-0_10