Effects of transcranial random noise stimulation combined with Graded Repetitive Arm Supplementary Program (GRASP) on motor rehabilitation of the upper limb in sub-acute ischemic stroke patients: a randomized pilot study.

6533b857fe1ef96bd12b4650

RESEARCH PRODUCT

Effects of transcranial random noise stimulation combined with Graded Repetitive Arm Supplementary Program (GRASP) on motor rehabilitation of the upper limb in sub-acute ischemic stroke patients: a randomized pilot study.

Valentina Arnao Filippo Brighina Marianna Riolo Massimo Gangitano Paolo Ragonese Antonino Tuttolomondo Francesca Carduccio Marco D'amelio Paolo Aridon Giuseppe Salemi

subject

0301 basic medicine Male Stroke rehabilitation medicine.medical_specialty Neurology Stimulation Pilot Projects Sub acute Transcranial Direct Current Stimulation Upper Extremity 03 medical and health sciences Transcranial random noise stimulation 0302 clinical medicine Physical medicine and rehabilitation Double-Blind Method medicine Humans Graded Repetitive Arm Supplementary Program (Grasp)Biological Psychiatry Physical Therapy Modalities Aged business.industry GRASP Transcranial random noise stimulation combined (tRNS)Brain Recovery of Function Combined Modality Therapy Motor rehabilitation Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Treatment Outcome Neurology Ischemic stroke Upper limb Female Settore MED/26 - Neurologia Neurology (clinical)business 030217 neurology & neurosurgery

description

We evaluated the combined use of transcranial random noise stimulation (tRNS) with the Graded Repetitive Arm Supplementary Program (GRASP) in sub-acute ischemic stroke patients suffering from arm impairment. Eighteen ischemic stroke patients with upper limb disability were randomly assigned to either the GRASP + tRNS or GRASP + Sham stimulation group. Fugl-Meyer Assessment-Upper extremity (FMA-UE) was performed to evaluate upper limb impairment before treatment (T0), after the last stimulation (T1) and after 30 days (T2). At T1 and T2, beneficial effects in the tRNS group correlated with better FMA-UE score than sham stimulation group (p < 0.001) and these results did not correlate to stroke severity, because no associations were observed between National Institute of Health Stroke Scale and FMA UE T1 and T2. This study displayed a good feasibility and was the first to evaluate the use of tRNS in association with Grasp in sub-acute stroke survivors having arm impairment to improve arm motor recovery.

year	journal	country	edition	language
2019-10-01

10.1007/s00702-019-02087-9 http://hdl.handle.net/10447/379810