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RESEARCH PRODUCT
New phenolics, cytotoxicity and chemosystematic significance of Atriplex semibaccata
Thomas A. EfferthAkemi UmeyamaMidori SuenagaMasaaki NojiAbdelsamed I. ElshamyTarik A. MohamedMohamed-elamir F. Hegazysubject
chemistry.chemical_classificationAtriplexbiology010405 organic chemistryPlant ScienceTyraminebiology.organism_classification01 natural sciencesBiochemistry0104 chemical sciencesHeLa010404 medicinal & biomolecular chemistrychemistry.chemical_compoundFlavonolsBiochemistrychemistryAtriplex semibaccataCancer cellChenopodiaceaeCytotoxicityAgronomy and Crop ScienceBiotechnologydescription
Abstract The chemical characterization of the 70% hydromethanolic extract of Atriplex semibaccata (family: Chenopodiaceae) afforded a new methoxylated flavonol triglycoside, atrisemibaccatoside A (1), and a new lignanamide, (N-[(E)-m-hydroxycinnamoyl]tyramine (7), as well as, five known flavonols (2–6) and two lignanamides (8–9). The structures of the isolated compounds were established depending upon LR&HR-FAB-MS, 1D and 2D NMR spectroscopic analyses. The cytotoxic activity of the isolated compounds (1–4, and 7–9) was investigated. Compounds 7, 8 and 9 weakly inhibited the proliferation of leukemia CCRF-CEM cells with IC50 values of 78.5, 46.3, and 71.2 μg/ml, respectively, and exhibited no cytotoxicity against Hela and HSC-2 cancer cells. A chemosystematic significance study was evaluated depending upon the chemical constituents of A. semibaccata comparing with those of other Atriplex species.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-12-01 | Phytochemistry Letters |