6533b857fe1ef96bd12b4fdd
RESEARCH PRODUCT
7E olfactory receptor gene clusters and evolutionary chromosome rearrangements
T. HaafYing Yuesubject
Genome instabilityChromosomes Artificial BacterialGenome evolutionBiologyReceptors OdorantGenomeEvolution MolecularGene DuplicationGeneticsmedicineAnimalsHumansMolecular BiologyGeneIn Situ Hybridization FluorescenceGenetics (clinical)SyntenySegmental duplicationGene RearrangementMammalsGeneticsGenomeOlfactory receptorGenome HumanChromosome Mappingmedicine.anatomical_structureMultigene FamilyHuman genomedescription
Olfactory receptor (OR) genes of the 7E subfamily have been duplicated to multiple regions throughout the human genome. Segmental duplications containing 7E OR genes have been associated with both pathological and evolutionary chromosome rearrangements. Many of these breakpoint regions coincide with breaks of chromosomal synteny in the mouse, rat and/or chicken genomes. Collectively, these data suggest that 7E OR-containing regions represent hot spots of genomic instability.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-01-20 | Cytogenetic and Genome Research |