6533b857fe1ef96bd12b5168
RESEARCH PRODUCT
Genetics of hepatocellular carcinoma.
Henning Schulze-bergkamenAndreas TeufelStephan KanzlerPeter R. GalleArndt WeinmannFrank Staibsubject
GeneticsRegulation of gene expressionChromosome AberrationsModern medicineMutationCarcinoma HepatocellularMicroarray analysis techniquesLiver NeoplasmsGastroenterologyGenomicsGeneral MedicineDNA NeoplasmBiologyDNA Methylationmedicine.disease_causedigestive system diseasesGene expression profilingGene Expression Regulation NeoplasticEditorialDNA methylationmedicineHumansHuman genomeOligonucleotide Array Sequence AnalysisSignal Transductiondescription
The completely assembled human genome has made it possible for modern medicine to step into an era rich in genetic information and high-throughput genomic analysis. These novel and readily available genetic resources and analytical tools may be the key to unravel the molecular basis of hepatocellular carcinoma (HCC). Moreover, since an efficient treatment for this disease is lacking, further understanding of the genetic background of HCC will be crucial in order to develop new therapies aimed at selected targets. We report on the current status and recent developments in HCC genetics. Special emphasis is given to the genetics and regulation of major signalling pathways involved in HCC such as p53, Wnt-signalling, TGFbeta, Ras, and Rb pathways. Furthermore, we describe the influence of chromosomal aberrations as well as of DNA methylation. Finally, we report on the rapidly developing field of genomic expression profiling in HCC, mainly by microarray analysis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-05-19 | World journal of gastroenterology |