6533b858fe1ef96bd12b59ff
RESEARCH PRODUCT
Synthesis of trans-disubstituted-2,3-dihydrobenzofurans by a formal [4 + 1] annulation between para-quinone methides and sulfonium salts
Kari RissanenYing ZhiKun ZhaoDieter EndersCarolina Von Essensubject
kemiallinen synteesiAnnulation010405 organic chemistrySulfoniumOrganic ChemistryfuransPara-quinone010402 general chemistry01 natural sciencesCombinatorial chemistry0104 chemical sciencesfuraanitchemistry.chemical_compoundchemistryta116chemical synthesisdescription
An efficient protocol for the synthesis of trans-disubstituted-2,3-dihydrobenzofurans through [4 + 1] annulation of para-quinone methides with sulfonium salts has been developed. Under very mild conditions this unprecedented reaction occurs in good to excellent yields (up to 99%), offering a straightforward access to a variety of 2,3-dihydrobenzofurans.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 | Organic Chemistry Frontiers |