6533b858fe1ef96bd12b6168
RESEARCH PRODUCT
false
subject
0303 health sciencesbiologyArp2/3 complexActin remodelingmacromolecular substancesCell BiologyFilaminActin cytoskeletonGeneral Biochemistry Genetics and Molecular BiologyCell biology03 medical and health sciencesActin remodeling of neurons0302 clinical medicineProfilinbiology.proteinMDia1Molecular BiologyFilopodia030217 neurology & neurosurgery030304 developmental biologyDevelopmental Biologydescription
Controlling the position of the nucleus is vital for a number of cellular processes from yeast to humans. In Drosophila nurse cells, nuclear positioning is crucial during dumping, when nurse cells contract and expel their contents into the oocyte. We provide evidence that in nurse cells, continuous filopodia-like actin cables, growing from the plasma membrane and extending to the nucleus, achieve nuclear positioning. These actin cables move nuclei away from ring canals. When nurse cells contract, actin cables associate laterally with the nuclei, in some cases inducing nuclear turning so that actin cables become partially wound around the nuclei. Our data suggest that a perinuclear actin meshwork connects actin cables to nuclei via actin-crosslinking proteins such as the filamin Cheerio. We provide a revised model for how actin structures position nuclei in nurse cells, employing evolutionary conserved machinery.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-09-01 | Developmental Cell |