6533b858fe1ef96bd12b627f

RESEARCH PRODUCT

Oxygenation and Bioenergetic Status of Murine Fibrosarcomas

C. SchaeferPeter VaupelPaul Okunieff

subject

BioenergeticsCritical factorsmedicineCancer therapyCancer researchGenetic variabilityEpigeneticsOxygenationmedicine.symptomBiologyHypoxia (medical)Acidosis

description

The heterogeneity of cellular response to therapy is a major problem in non-surgical cancer therapy. This heterogeneity is influenced by both the genetic variability between different tumor cells and by epigenetic, physiological factors, such as the local metabolic milieu. A restriction of tumor microcirculation concomitant with regional hypoxia, nutrient depletion, accumulation of lactate, and an intensified tumor acidosis becomes evident during growth of many solid tumors1. These critical factors can greatly influence the efficiency of various non-surgical tumor therapies.

yearjournalcountryeditionlanguage
1992-01-01
https://doi.org/10.1007/978-1-4615-3428-0_16