6533b858fe1ef96bd12b62df
RESEARCH PRODUCT
Acid Dnase Activities In Peripheral, Mononuclear Blood Cells: A Possible Parameter To Detect Proliferating Cell Populations
P. GutjahrReitz Msubject
LymphocyteCellBiologyLymphocyte ActivationIsozymePeripheral blood mononuclear cellGeneral Biochemistry Genetics and Molecular Biologychemistry.chemical_compoundReference ValuesmedicineHumansDeoxyribonuclease IILymphocyteschemistry.chemical_classificationDeoxyribonucleasesCell growthfood and beveragesDNAHydrogen-Ion ConcentrationPrecursor Cell Lymphoblastic Leukemia-LymphomaIsoenzymesmedicine.anatomical_structureEnzymeBiochemistrychemistryElectrophoresis Polyacrylamide GelIsoelectric FocusingDNAdescription
After electrophoresis in DNA -containing polyacrylamide gels, two acid DNase activities can be detected in peripheral, mononuclear cells of the human blood. One of these acid DNase activities correlates with cell proliferation; its isoelectrical point is at pI 7.4. By means of this DNase activity, a quantity of less than 1% leukemic cells can be detected. The increased acid DNase activity can indicate the proliferation of malignant cell populations and possibly the proliferation of cell populations during immunological reactions
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-12-01 | Zeitschrift für Naturforschung C |