Dopamine D2/D3 receptor availability and venturesomeness.

6533b858fe1ef96bd12b660b

RESEARCH PRODUCT

Dopamine D2/D3 receptor availability and venturesomeness.

Igor Yakushev Ingo Vernaleken Peter Bartenstein Peter Bartenstein Michael N. Smolka Christoph Fehr Nina Bernow Klaus Lieb Gerhard Gründer Christian Landvogt Hans-georg Buchholz Mathias Schreckenberger

subject

Adult Male Self-Assessment Pyrrolidines Statistics as Topic Neuroscience (miscellaneous)Neuropsychological Tests Impulsivity Statistical parametric mapping Personality Assessment Brain mapping Developmental psychology Cohort Studies Young Adult Risk-Taking Dopamine receptor D3 Dopamine receptor D2 Surveys and Questionnaires medicine Humans Radiology Nuclear Medicine and imaging Temporal cortex Brain Mapping Receptors Dopamine D2 Brain Psychiatry and Mental health Fallypride Positron-Emission Tomography Benzamides Impulsive Behavior medicine.symptom Personality Assessment Inventory Psychology Neuroscience

description

The construct of impulsivity is considered as a major trait of personality. There is growing evidence that the mesolimbic dopamine system plays an important role in the modulation of impulsivity and venturesomeness, the two key components within the impulsivity-construct. The aim of the present study was to explore an association between trait impulsivity measured with self-assessment and the dopaminergic neurotransmission as measured by positron emission tomography (PET) in a cohort of healthy male subjects. In vivo D2/D3 receptor availability was determined with [(18)F]fallypride PET in 18 non-smoking healthy subjects. The character trait impulsivity was measured using the Impulsiveness-Venturesomeness-Empathy questionnaire (I7). Image processing and statistical analysis was performed on a voxel-by-voxel basis using statistical parametric mapping (SPM) software. The I7 subscale venturesomeness correlated positively with the D2/D3 receptor availability within the left temporal cortex and the thalamus. Measures on the I7 subscale impulsiveness and empathy did not correlate with the D2/D3 receptor availability in any brain region investigated. Our results suggest the involvement of extrastriatal dopaminergic neurotransmission in venturesomeness, a component of impulsivity.

year	journal	country	edition	language
2011-08-01	Psychiatry research

10.1016/j.pscychresns.2011.01.011 https://pubmed.ncbi.nlm.nih.gov/21689908