6533b858fe1ef96bd12b6b3c
RESEARCH PRODUCT
Parasites Dampen Dendritic Cell Activation to Ensure Their Survival
Esther Von Stebutsubject
0301 basic medicineProtective immunityLigandLectinmacromolecular substancesDendritic cellBiologybiology.organism_classificationCell biology03 medical and health sciences030104 developmental biologyInfectious Diseasesbiology.proteinParasite hostingParasitologyParasite transmissionLeishmania majordescription
Dendritic cells (DCs) are critical for induction of protective immunity against Leishmania major. However, DC activation occurs only several weeks after parasite transmission. Parasites synthesize a macrophage-inducible C-type lectin (Mincle) ligand. Engagement of Mincle by the parasite ligand dampens DC activation, thus delaying induction of interferon-γ-producing T cells responsible for parasite eradication.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-02-01 | Trends in Parasitology |