6533b858fe1ef96bd12b6bfd
RESEARCH PRODUCT
‐Aminonitriles: From Sustainable Preparation to Applications in Natural Product Synthesis
Nina VierengelCaroline GrundkeTill Opatzsubject
Natural productPersonal account010405 organic chemistryComputer scienceGeneral Chemical EngineeringIndustrial scaleTotal synthesisGeneral Chemistry010402 general chemistry01 natural sciencesBiochemistry0104 chemical scienceschemistry.chemical_compoundchemistryMaterials ChemistryBiochemical engineeringdescription
Due to their numerous reactivity modes, α-aminonitriles represent versatile and valuable building blocks in organic total synthesis. Since their discovery by Adolph Strecker in 1850, this compound class has seen a wide dissemination in synthetic applications from laboratory to million-ton industrial scale and was extensively used in the syntheses of various classes of natural products. As these compounds provide a multitude of reactivity options, we feel that a broad overview of their multiple reaction modes may reveal less familiar opportunities for successful total synthesis planning. This personal account article will thus focus on α-aminonitriles used as key intermediates in selected natural product synthesis sequences which have been reported in the two decades since Enders' and Shilvock's seminal review. Natural α-aminonitriles will also briefly be treated.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-07-24 | The Chemical Record |