6533b858fe1ef96bd12b6d32
RESEARCH PRODUCT
Potential role of branched-chain amino acid catabolism in regulating fat oxidation.
Heikki KainulainenUrho M. KujalaJuha J. Hulmisubject
chemistry.chemical_classificationCatabolismChemistryBranched-chain amino acidPhysical Therapy Sports Therapy and RehabilitationAmino acidProtein catabolismchemistry.chemical_compoundFat oxidationBiochemistryAdipose TissueGlyceroneogenesisAnimalsHumansOrthopedics and Sports MedicineObesityMuscle SkeletalBeta oxidationExerciseOxidation-ReductionAerobic capacityAmino Acids Branched-Chaindescription
Insulin-resistant or obese individuals have increased serum branched-chain amino acid (BCAA) levels. Recent findings relate increased BCAA catabolism to increased fatty acid oxidation and better metabolic health in physically active individuals. We hypothesize that, via glyceroneogenesis, BCAA catabolism mediates increased constitutive use of fatty acids for β-oxidation in subjects with increased inherent or acquired aerobic capacity both during exercise and at rest.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-10-01 | Exercise and sport sciences reviews |