A selective inhibitor of the Polo-box domain of Polo-like kinase 1 identified by virtual screening

6533b858fe1ef96bd12b6db2

RESEARCH PRODUCT

A selective inhibitor of the Polo-box domain of Polo-like kinase 1 identified by virtual screening

Thomas A. Efferth Angela Berg Madeleine Böckers Sara Abdelfatah

subject

0301 basic medicine LK Polo-like kinase Polo-like kinase Cell cycle IC50 50% inhibition concentration Virtual drug screening PLK1 03 medical and health sciences 0302 clinical medicine Neoplasms Targeted chemotherapy lcsh:Science (General)Mitosis ComputingMethodologies_COMPUTERGRAPHICS CDK cyclin-dependent kinase PBD Polo-box domain PyRx Natural products lcsh:R5-920 Multidisciplinary Microscale thermophoresis Kinase Chemistry Cell cycle Cell biology 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell Original Article CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2 PC Polo-box cap lcsh:Medicine (General)Multipolar spindles lcsh:Q1-390

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Graphical abstract

year	journal	country	edition	language
2018-08-17	Journal of Advanced Research

10.1016/j.jare.2018.10.002 http://www.sciencedirect.com/science/article/pii/S2090123218301073

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