6533b859fe1ef96bd12b6f3e
RESEARCH PRODUCT
A Model of Smart G-Quadruplex Ligand
Romain HaudecoeurFranck DenatLoic StefanDavid Monchaudsubject
Models Molecular0303 health sciencesMagnetic Resonance SpectroscopyDose-Response Relationship DrugStereochemistryLigandChemistryGeneral ChemistryNuclear magnetic resonance spectroscopy010402 general chemistryG-quadruplexLigands01 natural sciencesBiochemistryCatalysis0104 chemical sciencesG-QuadruplexesSmall Molecule Libraries03 medical and health sciencesColloid and Surface Chemistry[CHIM]Chemical Sciencesheterocyclic compoundsSelectivityComputingMilieux_MISCELLANEOUS030304 developmental biologydescription
An unprecedented strategy to control the quadruplex- vs duplex-DNA selectivity of a ligand is reported. We designed a compound whose structure can rearrange when it interacts with a G-quadruplex, thereby controlling its affinity. Thus, the first "smart G-quadruplex ligand" is reported, since this ligand experiences a structural change in the presence of quadruplexes but not in the presence of duplexes, ensuring a high level of quadruplex selectivity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-12-31 |