6533b859fe1ef96bd12b75df
RESEARCH PRODUCT
Radiosynthesis of 3-indolyl[1-11C]acetic acid for phyto-PET-imaging: An improved production procedure and formulation method
Wenchao QuAnna T. KunertAnna T. KunertMax PavenMax PavenJoanna S. FowlerBenjamin A. BabstRichard A. FerrieriDohyun KimYouwen XuMichael J. SchuellerDavid Alexoffsubject
Radiation exposureAcetic acidchemistry.chemical_compoundRadiationchemistryYield (chemistry)RadiosynthesisTotal synthesisHigh radiationSpecific activityPet imagingNuclear chemistrydescription
Abstract An improved production procedure and formulation method for the carbon-11 radiolabeled phytohormone, 3-indolyl-[l- 11 C]acetic acid ([ 11 C]IAA), was developed by modifying selected original reaction parameters. This updated procedure both doubled the yield (from 25.9±6.7% ( n =12) to 61.0±0.3% ( n =10)) and increased the concentration (0.2–0.4 GBq/0.15–0.3 mL), enabling us to provide the radiotracer [ 11 C]IAA suitable for in vivo phyto-PET-imaging studies. The specific activity was improved by more than a factor of three (26.7±5.6 GBq/µmol to 82.5±36.1 GBq/µmol). The total synthesis time for both production and formulation was 81.8±3.0 min ( n =10). In addition, a streamlined semi-remote controlled production system, containing five processing modules, was designed and built for routine [ 11 C]IAA production. This integrated system facilitated routine high radiation level production of [ 11 C]IAA while minimizing radiation exposure to the production chemists.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-09-01 | Applied Radiation and Isotopes |