6533b859fe1ef96bd12b7601
RESEARCH PRODUCT
Enantioselective synthesis of sabina ketone
Julia Pérez-prietoMario Barberissubject
chemistry.chemical_classificationchemistry.chemical_compoundKetonechemistryOrganic ChemistryDrug DiscoverySuccinic anhydrideEnantioselective synthesisOrganic chemistryEnantiomerBiochemistryCatalysisdescription
Both enantiomers of sabina ketone were efficiently prepared via an easy synthesis of 1-diazo-5-methylene-6-methylheptan-2-one, starting from succinic anhydride, followed by its highly enantioselective cyclization catalyzed by chiral dirhodium(II) compounds having ortho-metalated phosphines as ligands.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-08-01 | Tetrahedron Letters |