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RESEARCH PRODUCT
Chiral bis(amino alcohol)oxalamides as ligands for asymmetric catalysis. Ti(IV) catalyzed enantioselective addition of diethylzinc to aldehydes
Isabel FernándezAlicia Marco‐aleixandreJosé R. PedroGonzalo Blaysubject
Organic ChemistryEnantioselective synthesisAlcoholGeneral MedicineDiethylzincMedicinal chemistryCatalysisCatalysisInorganic Chemistrychemistry.chemical_compoundchemistryOrganic chemistryPhysical and Theoretical ChemistryTitanium isopropoxidedescription
Abstract Several chiral bis(aminoalcohol)oxalamides with C 2 -symmetry have been prepared and used as ligands for the enantioselective addition of diethylzinc to aromatic and aliphatic aldehydes. The reaction proceeds in the presence of titanium isopropoxide to give the corresponding ( S )-alcohols with ee up to 78%. In the absence of Ti(IV), the alcohols with the opposite configuration are obtained.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-03-01 | Tetrahedron: Asymmetry |