Diferenciācijas indukcijas izpēte pēc BRAF un mTOR inhibitoru apstrādes BRAF mutētās ādas melanomas šūnās

6533b859fe1ef96bd12b7b75

RESEARCH PRODUCT

Diferenciācijas indukcijas izpēte pēc BRAF un mTOR inhibitoru apstrādes BRAF mutētās ādas melanomas šūnās

Fēlikss Rūmnieks

subject

melanomas diferenciācija BRAF inhibīcija Bioloģija kombinētā BRAF-mTOR inhibīcija BRAF mutētā melanoma

description

Darba mērķis bija padziļināti izpētīt BRAF inhibīcijas un sekojoši kombinētās BRAF un mTOR inhiibīcijas ietkemi uz metastātiskās BRAF mutēās melanomas šūnu līnijas SKMel28 šūnu ciklu, dzīvotspēju un inducēto atgriezensiko epitelilālo diferenciāciju. Ar advancētām mikroskopijas un šūnu analīzes metodēm tika apskatīti šos procesus iespējami ietkmējošie mehānismi. BRAF inhibīcija ar Vemurafenib rezultējās melanomas šūnu epiteliālā diferenciācijā un G1 arestā. Kombinētā BRAF un mTOR inhibīcija šūnās pagarināja šūnu diferencētā fenotipa stadiju, kas norāda uz iespējamu PI3K ceļa iesaisti SKMel28 šūnu augšanas un proliferācijas procesos. Lai arī pēc kombinētās BRAF-mTOR inhibīcijas diferencētais fenotips tika saglabāts ilgāk, SKMel28 šūnas tik un tā atgriezās dediferencētajā stadijā caur uzkrātā p62 mediētu epiteliālo- mezenhimālo tranzīciju. Tika novērotas arī blastulām līdzīgas multinukleāras šūnas, kuras pie apstrādes tikai ar Vemurafenib netika novērotas.

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/59275

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