6533b859fe1ef96bd12b7f3e

RESEARCH PRODUCT

Synthesis and NMR configurational study of imidazo[2,1-b]thiazoles from 1H-1,4-diazepine-7(6H)-thiones

José BarluengaJ. JoglarFernando López OrtizRaquel Pérez CarlónSantos Fustero

subject

chemistry.chemical_compoundDiazepineBicyclic moleculeHeteronuclear moleculechemistryIntramolecular reactionStereochemistryOrganic ChemistryDrug DiscoveryIntramolecular cyclizationNuclear magnetic resonance spectroscopyBiochemistry

description

Abstract A thermal intramolecular cyclization of 1-vinyl2,3-dihydro-3 H -imidazole-2-thiones to imidazo[2,1-b]thiazoles is reported. A heteronuclear correlation study of these systems was made in order to establish the configuration of the products.

https://doi.org/10.1016/s0040-4020(01)81831-7