Persistencia y seguridad del apremilast en el tratamiento de la psoriasis en la práctica clínica habitual: experiencia en 30 pacientes

6533b859fe1ef96bd12b7fc8

RESEARCH PRODUCT

Persistencia y seguridad del apremilast en el tratamiento de la psoriasis en la práctica clínica habitual: experiencia en 30 pacientes

Antonio Sahuquillo-torralba R. Botella Estrada E. Monte Boquet M. Rodríguez Serna B. De Unamuno Bustos

subject

030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine business.industry Medicine General Medicine business Humanities 030215 immunology

description

Resumen El apremilast es un inhibidor via oral de la fosfodiesterasa-4 con pocos datos de practica clinica habitual. Nuestro objetivo fue evaluar la persistencia y la seguridad del apremilast en la practica clinica en distintas formas clinicas de psoriasis. Se realizo un estudio observacional retrospectivo de los 30 pacientes con psoriasis que recibieron el farmaco entre enero de 2016 y diciembre de 2017 en nuestro centro, 10 con psoriasis en placas, 8 con placas predominantemente en el cuero cabelludo y 12 palmo-plantares. El tiempo global de probabilidad de supervivencia del 50% fue de 18,5 meses. En nuestra experiencia, el apremilast es un farmaco efectivo y seguro para la psoriasis en placas y palmo-plantar, no asi para la afectacion del cuero cabelludo. Los efectos secundarios ocurren en casi dos tercios de los pacientes comprometiendo la persistencia del tratamiento.

year	journal	country	edition	language
2020-06-01	Actas Dermo-Sifiliográficas

https://doi.org/10.1016/j.ad.2018.10.031

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