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RESEARCH PRODUCT

Coordination behavior of sulfathiazole. Crystal structure of [Cu (sulfathiazole) (py)3Cl] superoxide dismutase activity

Julio LatorreGloria AlzuetJoaquín BorrásSantiago García-grandaMercedes SanaúJ. Casanova

subject

ChemistryHydrogen bondSuperoxide dismutase activityCrystal structureChromophoreBiochemistryInorganic ChemistryCrystallographySulfathiazoleDeprotonationmedicineOrthorhombic crystal systemFree drugmedicine.drug

description

Abstract The preparation, spectroscopic, magnetic properties, and crystal structure of [Cu(stzxpy) 3 Cl] (stz − stands for the deprotonated form of sulfathiazole, 4-amino-N-2-thiazolylbencenosulfonamide) are reported. Crystals are orthorhombic, space group Pbca, with cell constants a = 15.834(2), b = 17.512(4), and c = 18.79(2) A, and Z = 8. The structure was solved and refined to R = 0.041 (R W = 0.040). The structure consists of mononuclear units linked via hydrogen bonds to form the tridimensional pyramid. The geometry of CuN3N*NCl chromophore is distorted square-pyramid. The superoxide-dismutase mimetic activity of the compound is measured and compared with those of the SOD enzyme, the free drug, and other related sulfathiazole complexes.

yearjournalcountryeditionlanguage
1995-11-01Journal of Inorganic Biochemistry
https://doi.org/10.1016/0162-0134(95)00022-g