Multi-objective optimization of nitinol stent design.

6533b859fe1ef96bd12b80de

RESEARCH PRODUCT

Multi-objective optimization of nitinol stent design.

Massimiliano Zingales Gianluca Alaimo Ferdinando Auricchio Michele Conti

subject

Engineering Compressive Strength medicine.medical_treatment 02 engineering and technology 030204 cardiovascular system & hematology computer.software_genre Multi-objective optimization 0302 clinical medicine Stent Computer Aided Design Fatigue Safety factor Structural engineering Equipment Design Fatigue limit Finite element method surgical procedures operative Computer-Aided Design Stents Algorithms 0206 medical engineering Finite Element Analysis Biophysics Biomedical Engineering Fatigue; Multi-objective optimization; Nitinol; Stent; Structural finite element analysis; Tapered strut; Biophysics; Biomedical Engineering 03 medical and health sciences Blood vessel prosthesis Elastic Modulus Tensile Strength Genetic algorithm medicine Alloys Pressure Computer Simulation cardiovascular diseases business.industry Stent Structural finite element analysi Nitinol Models Theoretical equipment and supplies 020601 biomedical engineering Tapered strut Blood Vessel Prosthesis Multi-objective optimization Equipment Failure Analysis Biophysic Stress Mechanical business computer

description

Nitinol stents continuously experience loadings due to pulsatile pressure, thus a given stent design should possess an adequate fatigue strength and, at the same time, it should guarantee a sufficient vessel scaffolding. The present study proposes an optimization framework aiming at increasing the fatigue life reducing the maximum strut strain along the structure through a local modification of the strut profile.The adopted computational framework relies on nonlinear structural finite element analysis combined with a Multi Objective Genetic Algorithm, based on Kriging response surfaces. In particular, such an approach is used to investigate the design optimization of planar stent cell.The results of the strut profile optimization confirm the key role of a tapered strut design to enhance the stent fatigue strength, suggesting that it is possible to achieve a marked improvement of both the fatigue safety factor and the scaffolding capability simultaneously. The present study underlines the value of advanced engineering tools to optimize the design of medical devices.

year	journal	country	edition	language
2017-09-01	Medical engineeringphysics

10.1016/j.medengphy.2017.06.026 https://pubmed.ncbi.nlm.nih.gov/28705512