6533b859fe1ef96bd12b80f8
RESEARCH PRODUCT
In situ delivery of corticosteroids for treatment of oral diseases.
Libero Italo GiannolaViviana De CaroFlavia Maria Suterasubject
Drugcorticosteroidmedicine.medical_specialtymedia_common.quotation_subjectMucocutaneous zonePharmaceutical ScienceOral cavitySystemic therapy03 medical and health sciences0302 clinical medicineDrug Delivery Systemsin situ deliveryAdrenal Cortex HormonesMedicineHumansoral diseaseIntensive care medicinemedia_commonWrong drugbusiness.industryMouth Mucosa030206 dentistrySurgeryKey factorsSettore CHIM/09 - Farmaceutico Tecnologico Applicativo030220 oncology & carcinogenesisbusinessMouth DiseasesRetention timedescription
In many mucocutaneous disorders, corticosteroids therapy is currently central. Systemic therapy is restricted to severe disorders whereas topical applications are considered as the first-line treatment. The oral cavity environment, the medication form and other factors related to the delivery method are key factors for the therapy efficiency and effectiveness. Current marketed medications are not able to avoid wrong drug exposure and scarce patients’ compliance. Innovative in situ delivery systems are able to prolong the drug retention time on the mucosa and to avoid the drawbacks of conventional formulations. This review is intended to give a general overview of oral mucocutaneous pathologies and highlight the potential of new technologies in designing innovative delivery systems able to release corticosteroids in situ for the treatment of various oral cavity disorders.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-10-01 | Therapeutic delivery |