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RESEARCH PRODUCT
Mild cognitive impairment is associated with fall-related injury among adults aged ≥65 years in low- and middle-income countries.
Hans OhAi KoyanagiBriona A. PfeiferLee SmithLouis JacobLin YangGuillermo F. López-sánchezLaurie T. ButlerNicola VeronesePinar SoysalKarel KostevYvonne BarnettIgor Grabovacsubject
Male0301 basic medicineChinaAgingIndiaPoison controlLogistic regressionGhanaBiochemistrySuicide preventionOccupational safety and healthRussiaOdds*Low-and-middle-income countriesSouth Africa03 medical and health sciencesOlder adults.0302 clinical medicineEndocrinologyRisk FactorsFall-related injuryInjury preventionmental disorders*Fall-related injuryPrevalenceGeneticsHumansMedicine*Mild cognitive impairmentCognitive DysfunctionDeveloping CountriesMexicoMolecular BiologyAged*Older adultsbusiness.industryConfoundingMild cognitive impairmentHuman factors and ergonomicsSmith L. Jacob L. Kostev K. Butler L. Barnett Y. Pfeifer B. Soysal P. Grabovac I. López-Sánchez G. F. Veronese N. et al. -Mild cognitive impairment is associated with fall-related injury among adults aged ≥65 years in low- and middle-income countries.- Experimental gerontology ss.111222 2020Cell BiologyCross-Sectional Studies030104 developmental biologyLow-and-middle-income countrieAccidental FallsFemalebusiness030217 neurology & neurosurgeryDemographydescription
Abstract Objectives There is a scarcity of data on the association between mild cognitive impairment (MCI) and falls, especially from low- and middle-income countries (LMICs) where 70% of all older adults reside. Thus, we investigated the association between MCI and fall-related injury among older adults residing in six LMICs (China, Ghana, India, Mexico, Russia, South Africa). Design Cross-sectional, community-based data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. Methods The definition of MCI was based on the National Institute on Ageing-Alzheimer's Association criteria, and information on past 12-month fall-related injury was also collected. Multivariable logistic regression analysis was conducted to assess associations. Results The analytical sample consisted of 13,623 individuals aged ≥65 years [mean (SD) age 72.3 (10.9) years; 45.6% males]. The prevalence of fall-related injury was higher among those with MCI (6.3%) vs. no MCI (4.1%). After adjustment for potential confounders, MCI was associated with a 1.53 (95%CI = 1.12–2.07) times higher odds for fall-related injury. Conclusions MCI was associated with higher odds for fall-related injury among older adults in LMICs. Future studies are warranted to investigate the mechanisms underlying this association and to elucidate whether targeting those with MCI can lead to reduced risk for falls among older adults.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 |