6533b859fe1ef96bd12b832a

RESEARCH PRODUCT

Development and In Vitro Evaluation of Lyotropic Liquid Crystals for the Controlled Release of Dexamethasone.

Maria Palmira Daflon GremiãoMarcia Helena OyafusoAna Luiza R. De SouzaDaniele Ribeiro De AraujoTatiane M. TakeshitaMarlus ChorilliFlávia Chiva CarvalhoVirginia Merino

subject

Materials sciencePolymers and PlasticsAmphiphilic polymersdexamethasone02 engineering and technology030226 pharmacology & pharmacyArticleDexamethasonelcsh:QD241-44103 medical and health scienceschemistry.chemical_compound0302 clinical medicinelcsh:Organic chemistryLyotropicControlled releaseNanostructured systemsLamellar structurelyotropic liquid crystalsIsopropyl myristatedrug releasechemistry.chemical_classificationPolarized light microscopyChromatographySmall-angle X-ray scatteringfungiDrug releaseGeneral ChemistryPolymerkinetic modelKinetic modelamphiphilic polymers; lyotropic liquid crystals; controlled release; drug release; kinetic model; dexamethasone; nanostructured systems021001 nanoscience & nanotechnologyControlled releaseLyotropic liquid crystalschemistryChemical engineeringnanostructured systemsLyotropic liquid crystal0210 nano-technologycontrolled releaseamphiphilic polymers

description

Made available in DSpace on 2018-12-11T17:33:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-08-02 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) In this study, amphiphilic polymers were investigated as biomaterials that can control dexamethasone (DXM) release. Such materials present interfacial properties in the presence of water and an oily phase that can result in lyotropic liquid crystalline systems (LLCS). In addition, they can form colloidal nanostructures similar to those in living organisms, such as bilayers and hexagonal and cubic phases, which can be exploited to solubilize lipophilic drugs to sustain their release and enhance bioavailability. It was possible to obtain lamellar and hexagonal phases when combining polyoxyethylene (20) cetyl ether (CETETH-20) polymer with oleic acid (OA), N-methylpyrrolidone (P), isopropyl myristate (IM), and water. The phases were characterized by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), rheological, textural, and bioadhesion analyses followed by an in vitro release assay. All samples showed elastic behavior in the rheology studies and hexagonal samples containing P and IM showed the highest adhesiveness. The drug release profile of all LLCS presented an average lag time of 3 h and was best fitted to the Korsmeyer-Peppas and Weibull models, with controlled release governed by a combination of diffusion and erosion mechanisms. These systems are potential carriers for DXM and can be explored in several routes of administration, providing potential advantages over conventional pharmaceutical forms. School of Pharmaceutical Sciences São Paulo State University (UNESP) School of Pharmaceutical Sciences Federal University of Alfenas UNIFAL-MG Human and Natural Sciences Center Federal University of ABC Instituto Interuniversitario Reconocimiento Molecular y Desarrollo Tecnológico Departamento de Farmacia y Tecnología Farmacéutica y Parasitología Universidad de Valencia School of Pharmaceutical Sciences São Paulo State University (UNESP) CAPES: #1241/2014

yearjournalcountryeditionlanguage
2017-08-01Polymers
10.3390/polym9080330https://pubmed.ncbi.nlm.nih.gov/30971006