Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential Antitumor Vaccines

6533b859fe1ef96bd12b83f7

RESEARCH PRODUCT

Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential Antitumor Vaccines

Lutz Nuhn Bastian Gerlitzki Björn Palitzsch Sebastian Hartmann Rudolf Zentel Edgar Schmitt Horst Kunz

subject

Synthetic vaccine Molecular Sequence Data Epitopes T-Lymphocyte Cancer Vaccines Catalysis Epitope Mice chemistry.chemical_compound Polymethacrylic Acids Antigen Animals Humans Methacrylamide Amino Acid Sequence MUC1 Vaccines Synthetic biology Mucin-1 Glycopeptides Toxoid Water T-Lymphocytes Helper-Inducer General Chemistry Molecular biology Glycopeptide Solubility Biochemistry chemistry MCF-7 Cells biology.protein Antibody

description

Highly decorated: Tumor-associated MUC1 glycopeptide and tetanus toxoid T-cell epitope P2 can be attached to water-soluble poly(N-(2-hydroxypropyl)methacrylamide) carriers by orthogonal ligation techniques. Fully synthetic vaccine A with additional nanostructure-promoting domains induced antibodies that exhibit high affinity to tumor cells.

year	journal	country	edition	language
2013-08-26	Angewandte Chemie International Edition

https://doi.org/10.1002/anie.201304212

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