6533b859fe1ef96bd12b8433
RESEARCH PRODUCT
A controlled and versatile NCA polymerization method for the synthesis of polypeptides
Alexander BirkeAroa Duro-castanoInmaculada Conejos-sánchezMaría J. VicentMatthias Barzsubject
TetrafluoroboratePolymers and PlasticsPolyglutamateChemistryOrganic ChemistryDispersityBioengineering02 engineering and technology010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesBiochemistryRing-opening polymerization0104 chemical scienceschemistry.chemical_compoundPolymerizationOrganic chemistryStereoselectivityNanocarriers0210 nano-technologydescription
A versatile and simple methodology for the preparation of well-defined polyglutamate nanocarriers is described. For the first time ammonium salts with non-nucleophilic tetrafluoroborate anions are used as initiators for the ring opening polymerization of alpha-N-carboxyanhydrides (NCAs) allowing a multigram scale polyglutamate synthesis with defined molecular weight (up to 800 units), low polydispersity (<1.2), controlled chain end functionality and adequate stereoselectivity and absence of any trace of toxic impurity to allow biomedical applications.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 |