6533b85afe1ef96bd12b8a3a
RESEARCH PRODUCT
ChemInform Abstract: Synthesis of Fluorinated Allylic Amines: Reaction of 2-(Trimethylsilyl)ethyl Sulfones and Sulfoxides with Fluorinated Imines.
Ana C. CuñatJuan F. Sanz-cerveraCarlos Del PozoSantos FusteroSonia FloresJorge BuenoDiego Jimenezsubject
chemistry.chemical_compoundAllylic rearrangementTrimethylsilylchemistryFragmentation (mass spectrometry)Organic chemistrySingle stepGeneral Medicinedescription
A new synthesis of fluorinated allylamines through the reaction of 2-(trimethylsilyl)ethyl sulfones and sulfoxides (as vinyl anion equivalents) with imines and imino esters has been described. The process includes a TBAF-mediated fragmentation of 2-(trimethylsilyl)ethyl sulfones to afford the desired allylic amines. When the reaction is performed with the corresponding sulfoxides, the fragmentation takes place under the addition conditions, affording the final products in a single step.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-02-12 | ChemInform |