6533b85afe1ef96bd12b8a6e
RESEARCH PRODUCT
Stereospecific CC-bond formation with rabbit muscle aldolase - A chemoenzymatic synthesis of (+)-exo-brevicomin
Walter VogtHorst KunzHerbert WaldmannM. Schultzsubject
chemistry.chemical_classificationKetonebiologyStereochemistryOrganic ChemistryAldolase AAbsolute configurationFructose-bisphosphate aldolasecomplex mixturesBiochemistryEnzyme catalysisStereospecificitychemistryAldol reactionDrug Discoverybiology.proteinAldol condensationdescription
Abstract (+)-(1S,5R,7S)-Exo-brevicomin 9, a sex pheromone of the western pine bark beetle, is synthesized using an aldol reaction catalyzed by fructose-1,6-diphosphate aldolase (EC 4.1.2.13) from rabbit muscle as the key step by which the absolute configuration of the target is established.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-01-01 | Tetrahedron Letters |