6533b85afe1ef96bd12b8b2f

RESEARCH PRODUCT

Uncovering Metabolic Effects of Anti-angiogenic Therapy in Tumors by Induced Metabolic Bioluminescence Imaging

Stefano IndraccoloStefan WalentaWolfgang Mueller-klieser

subject

0301 basic medicineChemistryAngiogenesisAnti angiogenic03 medical and health sciences030104 developmental biology0302 clinical medicineAbsolute amount030220 oncology & carcinogenesisMetabolic effectsCancer researchBioluminescence imagingBioluminescenceDistribution (pharmacology)Glycolysis

description

Induced metabolic bioluminescence imaging (imBI) is an imaging technique which enables detection of various metabolites associated with glycolysis in tumor sections. Signals captured by imBI can be used to chart the topographic distribution of lactate, glucose, pyruvate, and ATP and quantify their absolute amount. ImBi can enable us to perform metabolic classification of tumors as well as to detect metabolic changes in the glycolytic pathway associated with certain therapies, such as anti-angiogenic drugs.

yearjournalcountryeditionlanguage
2016-01-01
https://doi.org/10.1007/978-1-4939-3999-2_16