6533b85afe1ef96bd12b8d2a

RESEARCH PRODUCT

Effects of resistance training on testosterone metabolism in younger and older men

Kai NymanTapani ParviainenMika HelsteAntti RannikkoKeijo HäkkinenJuha P. AhtiainenWilliam J. KraemerIlpo Huhtaniemi

subject

AdultMaleLuteinizing hormoneAgingmedicine.medical_specialtyta3111AndrosteroneBiochemistryMuscle hypertrophychemistry.chemical_compoundEndocrinologySex hormone-binding globulinInternal medicineEtiocholanoloneGeneticsmedicineHumansTestosteroneMuscle Skeletalta315ExerciseMolecular BiologyTestosteroneAgedEtiocholanoloneAndrosteronebiologyta1184Age FactorsResistance TrainingCell BiologyHypothalamic–pituitary–thyroid axisPatient Outcome AssessmentRenal EliminationAndrogen receptorEndocrinologychemistryReceptors AndrogenIsotope LabelingGnRHbiology.proteinLuteinizing hormoneHormonemedicine.drug

description

This study investigated the effects of resistance training (RT) on the metabolism of testosterone (T) in younger (n=5, 28±3yrs.) and older (n=8, 70±2yrs.) men. Experimental heavy resistance exercises (5×10RM leg presses) were performed before and after a 12-month of RT. No age differences were found in the production or metabolic clearance rate of T (determined by stable isotope dilution method), skeletal muscle androgen receptor content or serum LH concentrations due to acute or chronic RT. The T production capacity response to gonadotropin stimulation and the concentrations of the urinary T metabolites (androsterone and etiocholanolone) were lower in the older compared to younger men (p<0.05-0.01). This study further showed that RT may have acute effect on T production and clearance rates, while the exercise-induced increases in serum T appeared to be induced by decreased metabolic clearance rate of T. Attenuated T production capacity and urinary excretion of T metabolites in older men may reflect the known reduction in testicular steroidogenesis upon aging. No changes were observed in T metabolism due to RT indicating a homeostatic stability for this hormone in men of different ages.

yearjournalcountryeditionlanguage
2015-01-01Experimental Gerontology
https://doi.org/10.1016/j.exger.2015.06.010