Extracellular vesicles in the oligodendrocyte microenvironment

6533b85afe1ef96bd12b8d73

RESEARCH PRODUCT

Extracellular vesicles in the oligodendrocyte microenvironment

Eva-maria Krämer-albers

subject

0301 basic medicine Biology Nerve Fibers Myelinated Extracellular vesicles Neuroprotection Extracellular Vesicles 03 medical and health sciences 0302 clinical medicine Neuroplasticity medicine Animals Humans Myelin Sheath Tissue homeostasis General Neuroscience Oligodendrocyte Microvesicles Cell biology Oligodendroglia Crosstalk (biology)030104 developmental biology medicine.anatomical_structure Cellular Microenvironment nervous system 030217 neurology & neurosurgery Homeostasis Signal Transduction

description

Abstract Extracellular vesicles (EVs) recently took centre stage as mediators of cellular crosstalk modulating the tissue microenvironment. Released by all types of neural cells, EVs may execute a broad spectrum of functions ranging from maintenance of neuronal homeostasis and regulation of neural plasticity to the spread of neurodegenerative agents. Myelinating oligodendrocytes and axons form a highly specialized functional entity that depends on intimate interactions within the oligodendrocyte-neuron niche. EVs released by oligodendrocytes are internalized by neurons in response to neuronal signals and exhibit neuroprotective properties but also may influence other cells present in the microenvironment. Here we discuss the role of EVs released by oligodendrocytes in regulating development, homeostatic maintenance and regeneration within the oligodendrocyte niche.

year	journal	country	edition	language
2019-12-08	Neuroscience Letters

https://doi.org/10.1016/j.neulet.2020.134915

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