6533b85afe1ef96bd12b8dd8
RESEARCH PRODUCT
Electrochemical synthesis of sulfamides.
Siegfried R. WaldvogelStephan P. BlumDieter SchollmeyerLukas Schäffersubject
chemistry.chemical_classificationChemistrySupporting electrolyteIodideMetals and AlloysGeneral ChemistryElectrochemistrycomplex mixturesCombinatorial chemistryCatalysisrespiratory tract diseasesSurfaces Coatings and FilmsElectronic Optical and Magnetic Materialschemistry.chemical_compoundFunctional groupMaterials ChemistryCeramics and CompositesStock solutiondescription
Herein we demonstrate the first electrochemical synthesis protocol of symmetrical sulfamides directly from anilines and SO2 mediated by iodide. Sulfamides are an emerging functional group in drug design. Highlights are the direct use of SO2 from a stock solution and no necessity of any supporting electrolyte. Overall, the reaction has been demonstrated for 15 examples with yields up to 93%.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-04-21 | Chemical communications (Cambridge, England) |