6533b85afe1ef96bd12b8dea

RESEARCH PRODUCT

SARS-CoV-2 mRNA Vaccine Breakthrough Infections in Fully Vaccinated Healthcare Personnel: A Systematic Review

Caterina LeddaClaudio CostantinoGiuseppe MottaRosario CunsoloPatrizia StracquadanioGiuseppe LibertiHelena C. MaltezouVenerando Rapisarda

subject

General Immunology and MicrobiologySARS-CoV-2pandemicRPublic Health Environmental and Occupational HealthCOVID-19vaccinationmRNA-1273Infectious DiseasesTAK-919MedicineBNT162b2Systematic Reviewpost-vaccinationasymptomatic infectionhealthcare personnel

description

The number of people vaccinated against COVID-19 increases worldwide every day; however, it is important to study the risk of breakthrough infections in vaccinated individuals at high risk of exposure such as healthcare personnel (HCP). A systematic literature review (SLR) applying the PRISMA declaration and the PECOS format using the following entry terms was used: “Health Personnel OR Healthcare Worker OR Healthcare Provider OR Healthcare Personnel AND breakthrough OR infection after vaccine*”. The research was carried out utilizing the following databases: SCOPUS, PubMed, Embase, and Web of Sciences. An overall very low incidence of post-vaccination breakthrough infections was found, ranging from 0.011 to 0.001 (per 100 individuals at risk). Our findings further support the published high effectiveness rates of mRNA vaccines in preventing SARS-CoV-2 infections among fully vaccinated HCP. Additional studies are needed to define the duration of the vaccine-induced protection among HCP.

yearjournalcountryeditionlanguage
2022-01-01
10.3390/tropicalmed7010009http://hdl.handle.net/20.500.11769/518425