6533b85afe1ef96bd12b8e59
RESEARCH PRODUCT
Regional distribution of high-affinity L-tryptophan uptake in rat brain
S.h.j. HöckelWerner E.g. MüllerUwe Wollertsubject
General NeuroscienceBiophysicsTryptophanDistribution (pharmacology)SerotoninBiologySerotonergicRat brainNeurosciencedescription
Abstract L-tryptophan is accumulated by slices of seven regions of the rat brain in a saturable, energy-depending fashion, with K m -values ranging from 53 to 142 μM. The maximal number of L-tryptophan accumulating sites differs only by about two-fold for the brain regions investigated. The regional distribution of the high-affinity L-tryptophan uptake does not correlate with the amount of serotonin synaptosomal uptake and apparent receptor binding. It is assumed that a specific role of the L-tryptophan uptake system within the serotoninergic system in the brain is questionable.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1978-04-01 | Neuroscience Letters |