6533b85afe1ef96bd12b8e5c
RESEARCH PRODUCT
Crystal structure and Hirshfeld surface analysis of 3-octyl-4-oxo-2,6-bis(3,4,5-trimethoxyphenyl)piperidinium chloride
Urooj IqbalShammim AkhterRubina SiddiquiSammer YousufZafar Saeed Saifysubject
crystal structureCyclohexane conformationCrystal structure010403 inorganic & nuclear chemistryRing (chemistry)01 natural sciencesMedicinal chemistryChlorideResearch CommunicationsCrystalchemistry.chemical_compoundMannich reactionmedicineHirshfeld surface analysisGeneral Materials ScienceBenzeneMannich reactionCrystallography010405 organic chemistryHydrogen bondChemistryGeneral ChemistryCondensed Matter Physics0104 chemical sciencesQD901-999piperidine-4-onemedicine.drugdescription
The title compound was synthesized by a one-pot Mannich condensation reaction. In the crystal, centrosymmetric dimers are linked into layers parallel to (011) by N—H⋯Cl and C—H⋯Cl hydrogen bonds. A Hirshfeld surface analysis indicates that O—H (20.5%) interactions make the largest contribution to the crystal packing.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-07-01 | Acta Crystallographica Section E Crystallographic Communications |