6533b85afe1ef96bd12b8e5d
RESEARCH PRODUCT
NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
Balistrericarmela RitaDomenico LioCandoregiuseppinaGiulia AccardiGiuseppina Colonna-romanosubject
AgingBiological ageInflammatory network and its effects in ageingImmunologyLarge arrayReviewWorking hypothesisBiological ageing processchemistry.chemical_compoundBiological ageing process Inflammatory network and its effects in ageing NF-κB signaling pathway as hub of inflammatory ageing network Inflammatory biomarkersSettore MED/05 - Patologia ClinicaMedicineSettore MED/04 - Patologia Generalebusiness.industryMechanism (biology)NF-κBInflammatory biomarkersRisk factor (computing)NF-κB signaling pathway as hub of inflammatory ageing networkInflammatory biomarkersAgeingchemistryAgeingImmunologybusinessNeurosciencedescription
Chronic inflammation is a major biological mechanism underpinning biological ageing process and age-related diseases. Inflammation is also the key response of host defense against pathogens and tissue injury. Current opinion sustains that during evolution the host defense and ageing process have become linked together. Thus, the large array of defense factors and mechanisms linked to the NF-κB system seem to be involved in ageing process. This concept leads us in proposing inductors of NF-κB signaling pathway as potential ageing biomarkers. On the other hand, ageing biomarkers, represented by biological indicators and selected through apposite criteria, should help to characterize biological age and, since age is a major risk factor in many degenerative diseases, could be subsequently used to identify individuals at high risk of developing age-associated diseases or disabilities. In this report, some inflammatory biomarkers will be discussed for a better understanding of the concept of biological ageing, providing ideas on eventual working hypothesis about potential targets for the development of new therapeutic strategies and improving, as consequence, the quality of life of elderly population.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-06-01 | Immunity & Ageing |