6533b85afe1ef96bd12b9640

RESEARCH PRODUCT

The role of angiogenesis in implant dentistry part II: the effect of bone-grafting and barrier membrane materials on angiogenesis

Nader SheibaniMohammad Ali SaghiriArmen AsatourianFranklin Garcia-godoy

subject

Bone RegenerationMaxillary sinusBarrier membranemedicine.medical_treatmentDentistryNeovascularization PhysiologicOdontologíaReviewBone graftingNeovascularization03 medical and health sciences0302 clinical medicinemedicineHumansDental implantBone regenerationGeneral DentistryDental ImplantsSocket preservationBone Transplantationbusiness.industryDental Implantation Endosseous030206 dentistryAlveolar Ridge AugmentationAlveolar Ridge AugmentationMaxillary Sinus:CIENCIAS MÉDICAS [UNESCO]Ciencias de la salud3. Good healthmedicine.anatomical_structureOtorhinolaryngology030220 oncology & carcinogenesisBone SubstitutesUNESCO::CIENCIAS MÉDICASSurgerymedicine.symptomOral Surgerybusiness

description

Background : In implant dentistry, bone substitute materials and barrier membranes are used in different treatments including guided bone regeneration (GBR), socket preservation, alveolar ridge augmentation, maxillary sinus elevation, and filling bony defects around the inserted dental implant. One of the most important factors in prognosis of treatments using these materials is the growth of new blood vessels in applied areas. Present review was performed to evaluate the effect of the bone-grafting and barrier membrane materials on angiogenesis events. Material and Methods : An electronic search was performed in PubMed, MEDLINE, and EMBASE databases via OVID using the keywords mentioned in the PubMed and MeSH headings regarding the role of angiogenesis in implant dentistry from January 2000-April 2014. Results: Of the 5,622 articles identified in our initial search results, only 33 met the inclusion criteria set for this review. Among bone substitute materials the autogenous bone-grafts, and among the barrier membranes the collagenous membranes, had the highest angiogenic potentials. Other bone-grafting materials or membranes were mostly used with pro-angiogenic factors to enhance their angiogenic properties. Conclusions: Angiogenesis is one of the key factors, which plays a critical role in success rate of GBR technique and is seriously considered in manufacturing bone-grafting and barrier membrane materials. However, there is still lack of clinical and in-vivo studies addressing the effect of angiogenesis in treatments using bone-grafting and barrier membrane materials.

http://hdl.handle.net/10550/54803