Role of Pir1 in the construction of the Candida albicans cell wall

6533b85afe1ef96bd12b9663

RESEARCH PRODUCT

Role of Pir1 in the construction of the Candida albicans cell wall

Eulogio Valentín Ana I. Martínez M V Elorza Ana Garcera Rafael Sentandreu Luis Castillo

subject

Saccharomyces cerevisiae Proteins beta-Glucans Sequence Homology Amino Acid Saccharomyces cerevisiae Nucleic acid sequence Saccharomyces cerevisiae Biology biology.organism_classification Microbiology Homology (biology)Epitope Corpus albicans Fungal Proteins Biochemistry Cell Wall Candida albicans Amino Acid Sequence Candida albicans Gene Peptide sequence Glycoproteins

description

Searches in a Candida albicans database (http://genolist.pasteur.fr/CandidaDB/) identified two Individual Protein Files (IPF 15363 and 19968) whose deduced amino acid sequences showed 42 % and 45 % homology with Saccharomyces cerevisiae Pir4. The two DNA sequences are alleles of the same gene (CaPIR1) but IPF 19968 has a deletion of 117 bases. IPF 19968 encodes a putative polypeptide of 364 aa, which is highly O-glycosylated and has an N-mannosylated chain, four cysteine residues and seven repeats. Both alleles are expressed under different growth conditions and during wall construction by regenerating protoplasts. The heterozygous mutant cells are elongated, form clumps of several cells and are hypersensitive to drugs that affect cell wall assembly. CaPir1 was labelled with the V5 epitope and found linked to the 1,3-beta-glucan of the C. albicans wall and also by disulphide bridges when expressed in S. cerevisiae.

year	journal	country	edition	language
2004-10-08

http://hdl.handle.net/10459.1/58445

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