Hipofīzes neiroendokrīno audzēju raksturīgo mikro RNS identificēšana un izpēte pacientu plazmā

6533b85afe1ef96bd12b9ab6

RESEARCH PRODUCT

Hipofīzes neiroendokrīno audzēju raksturīgo mikro RNS identificēšana un izpēte pacientu plazmā

subject

hipofīzes neiroendokrīnie audzēji cirkulējošās miRNS bilaterālā inferioro petrozālo sinusu katetrizācija Bioloģija diferenciālekspresijas analīze plazmas biomarķieri

description

Cirkulējošās plazmas mikro RNS (miRNS) ir plaši pētīts biomarķieris ļaundabīgo audzēju diagnostikā, bet saistībā ar hipofīzes neiroendokrīnajiem audzējiem (PitNET) tās ir maz izpētītas. Darbā, izmantojot nākamās paaudzes sekvencēšanu, tika analizētas miRNS izmaiņas pacientu plazmas paraugos pirms un 24 stundas pēc ekstirpācijas, kā arī novērtēts miRNS saturs plazmā no pacienta, kuram tika veikta bilaterālā inferioro petrozālo sinusu katetrizācija (BIPSS). Pirms un pēc ekstirpācijas cirkulējošo miRNS sastāvs tika analizētas 34 pacientos un diferenciālekspresijas analīzē statistiski būtiskas izmaiņas (P < 0,05) 24 stundas pēc PitNET ekstirpācijas tika detektētas 22 miRNS, no kurām 15 bija augšupregulētas, bet septiņas lejupregulētas. Salīdzinot plazmu no kreisā inferiorā petrozālā sinusa ar plazmu no labā inferiorā petrozālā sinusa, tika identificētas divas miRNS: miR-375-3p un miR-7-5p, kuras audzējs sekretē paralēli ACTH, kā atbildi uz CRH stimulāciju.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54477

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