The neuropeptide PACAP promotes ?‐secretase pathway for processing Alzheimer amyloid precursor protein

6533b85afe1ef96bd12b9e5e

RESEARCH PRODUCT

The neuropeptide PACAP promotes ?‐secretase pathway for processing Alzheimer amyloid precursor protein

Corinna Buro Katja Gehrig-burger Rolf Postina Falk Fahrenholz Elzbieta Kojro Christoph Meiringer

subject

MAP kinase kinase kinase biology Neuropeptide Mitogen-activated protein kinase kinase Cleavage (embryo)Biochemistry Alpha secretase Biochemistry mental disorders Genetics Amyloid precursor protein biology.protein ASK1 Molecular Biology Biotechnology G protein-coupled receptor

description

SPECIFIC AIMSProteolytic cleavage of the amyloid precursor protein (APP) by α-secretase within the Aβ sequence precludes formation of amyloidogenic peptides and leads to a release of soluble APPsα,...

year	journal	country	edition	language
2006-01-09	The FASEB Journal

https://doi.org/10.1096/fj.05-4812fje

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