6533b85afe1ef96bd12ba093
RESEARCH PRODUCT
The revised microRNA complement of Fasciola hepatica reveals a plethora of overlooked microRNAs and evidence for enrichment of immuno-regulatory microRNAs in extracellular vesicles
Dolores BernalMichael HackenbergMaría TrelisFernando CantalapiedraAntonio MarcillaBastian Frommsubject
ImmunomodulationExtracellular VesiclesImmune systemmicroRNAparasitic diseasesHelminthFasciola hepaticaAnimalsHumansGenemiRNAbiologyVesicleComputational BiologyGenomicsLiver flukeFasciola hepaticaExtracellular vesiclesbiology.organism_classificationCell biologyMicroRNAsInfectious DiseasesGene Expression RegulationImmunologyParasitologyTrematodaFunction (biology)description
MicroRNAs (miRNAs) are gene regulators that have recently been shown to down-regulate the immune response via extracellular vesicles in the mammalian host of helminthic parasites. Using the miRNA prediction pipeline miRCandRef, we expanded the current miRNA set of the liver fluke Fasciola hepatica (Platyhelminthes, Trematoda) from 16 to 54 miRNAs (42 conserved and 13 novel). Comparing the cellular expression levels with extracellular vesicles, we found all miRNAs expressed and enriched for miRNAs with immuno-regulatory function, tissue growth and cancer. Our findings support the hypothesis that miRNAs are the molecular mediators of the previously demonstrated immune modulatory function of extracellular vesicles. (C) 2015 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-09-01 |