6533b85bfe1ef96bd12ba241

RESEARCH PRODUCT

GPCR Inhibition in Treating Lymphoma

Marilia BarrecaVirginia SpanòMaria Valeria RaimondiRoberta BivacquaStefano GiuffridaAlessandra MontalbanoAndrea CavalliFrancesco BertoniPaola Barraja

subject

CXCR4G protein-coupled receptorsDLBCLOrganic ChemistryDrug DiscoverylymphomaMCLBiochemistryGPCRs

description

G protein-coupled receptors (GPCRs) are important classes of cell surface receptors involved in multiple physiological functions. Aberrant expression, upregulation, and mutation of GPCR signaling pathways are frequent in many types of cancers, promoting hyperproliferation, angiogenesis, and metastasis. Recent studies showed that alterations of GPCRs are involved in different lymphoma types. Herein, we review the synthetic strategies to obtain GPCR inhibitors, focusing on CXCR4 inhibitors which represent most of the GPCR inhibitors available in the market or under preclinical investigations for these diseases.

yearjournalcountryeditionlanguage
2022-02-15
10.1021/acsmedchemlett.1c00600http://hdl.handle.net/10447/537453