1.4 - dihidropiridīnu efekti uz kalcija kanāliem šūnās

6533b85bfe1ef96bd12ba456

RESEARCH PRODUCT

1.4 - dihidropiridīnu efekti uz kalcija kanāliem šūnās

Matīss Otersbergs

subject

description

Kalcija antagonisti jeb kalcija kanālu blokatori klīniskajā medicīnā tika ieviesti jau 20 gs. 60os gados. Šodien tās ir vienas no biežāk izrakstītajām zālēm kardiovaskulāro slimību ārstēšanā. 1.4-dihidropiridīns ir visefektīvākais dihidropiridīnu klases kalcija kanālu blokators, kam ir atklātas ne vien asinsspiedienu pazeminošas īpašības, bet arī pretvēža, antioksidanta un antimikrobiālo aģenta īpašības. Darba mērķis bija noteikt jauna 1,4-dihidropiridīna atvasinājuma A3-13 antioksidanta spēju in vitro testā un kalcija kanālu blokatora efektu SH-5YSH šūnu līnijā, kas ekspresē L- un N-tipa kalcija kanālus. Rezultāti rāda, ka A3-13 piemīt neliela (par 6-8%) brīvā radikāļa DPPH līmeņa samazināšanas spēja, kas raksturo tā antioksidanta potenciālu. A3-13 nepiemīt kalcija kanālu agonista īpašības, bet ar IC50 koncentrācijā 9 ± 3 μM šis savienojums uzrāda kalcija kanālu antagonista īpašības.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/18393

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