6533b85bfe1ef96bd12ba520

RESEARCH PRODUCT

INFIAMMAZIONE NEURO-MEDIATA E PATOLOGIE DELLA MUCOSA LINGUALE: UN'IPOTESI EZIOPATOGENETICA

Giuseppe Alessandro ScardinaAlessia RuggieriPietro Messina

subject

Settore MED/28 - Malattie Odontostomatologicheneurologic inflammation oral disease

description

The nervous system contributes to the pathophysiology of peripheral inflammation and a neurogenic component has been implicated in many inflammatory disease, including oral diseases. Neurogenic inflammation should be regarded as a protective mechanism wich forms the first line of defense and protects tissue integrity. However, prolonged noxius stimulation may result in the inflammatory response. This review focuses on the evidence suggesting that neuropeptides have a pivotal role in the complex cascade of chemical activity associated with oral diseases. The pathophysiology is complex and neuropeptides are not solely responsible for the initiation and progression of the disease. However, since neuropeptides and inflammatory modulators are released together during the inflammatory response, it will be impossible to assign a specific role to each until work with selective antagonists is completed.

yearjournalcountryeditionlanguage
2007-01-01
http://hdl.handle.net/10447/10984