6533b85bfe1ef96bd12babdf

RESEARCH PRODUCT

dAPE: a web server to detect homorepeats and follow their evolution.

Pablo MierMiguel A. Andrade-navarro

subject

0301 basic medicineStatistics and ProbabilityRepetitive Sequences Amino AcidWeb serverInternetComputer sciencecomputer.software_genreBiochemistryApplications NotesComputer Science ApplicationsWorld Wide WebEvolution Molecular03 medical and health sciencesComputational Mathematics030104 developmental biologyComputational Theory and MathematicsAnimalsHumansData miningMolecular BiologycomputerSequence AlignmentSequence AnalysisSoftware

description

Abstract Summary Homorepeats are low complexity regions consisting of repetitions of a single amino acid residue. There is no current consensus on the minimum number of residues needed to define a functional homorepeat, nor even if mismatches are allowed. Here we present dAPE, a web server that helps following the evolution of homorepeats based on orthology information, using a sensitive but tunable cutoff to help in the identification of emerging homorepeats. Availability and Implementation dAPE can be accessed from http://cbdm-01.zdv.uni-mainz.de/∼munoz/polyx. Supplementary information Supplementary data are available at Bioinformatics online.

yearjournalcountryeditionlanguage
2016-12-28Bioinformatics (Oxford, England)
10.1093/bioinformatics/btw790https://pubmed.ncbi.nlm.nih.gov/28031183