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RESEARCH PRODUCT
A roadmap for understanding the evolutionary significance of structural genomic variation
Claire MérotMaren WellenreutherMaren WellenreutherRebekah A. OomenRebekah A. OomenAnna Tiganosubject
0106 biological sciences0301 basic medicineFuture studiesEvolutionary significanceGenomicsCommon frameworkVariation (game tree)BiologyAdaptation PhysiologicalBiological Evolution010603 evolutionary biology01 natural sciencesPopulation genomics03 medical and health sciences030104 developmental biologyEvolutionary biologyChromosome InversionGenetic algorithmHumansMetagenomicsCopy-number variationAdaptationEcology Evolution Behavior and SystematicsVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480description
Author's accepted manuscript Structural genomic variants (SVs) take diverse forms and are ubiquitous drivers of ecological and evolutionary processes. Most studies of SVs focus on the adaptive significance of gene duplications and large inversions. Future studies should catalog SVs of all types and sizes and systematically test their evolutionary implications. We propose a roadmap and definitions for the study of SVs in ecological and evolutionary genomics. Best practices for SV detection are needed to facilitate comparisons across studies. Integrating population genomic, theoretical, and experimental approaches to SVs will more comprehensively characterize genomic variation, uncover the adaptive and neutral processes shaping the evolutionary trajectory of SVs, and identify the mechanisms by which SVs impact adaptation and speciation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 |