Jaunsintezētu multiheterociklisku savienojumu antimikrobiālā aktivitāte un iespējamais darbības mehanisms

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Jaunsintezētu multiheterociklisku savienojumu antimikrobiālā aktivitāte un iespējamais darbības mehanisms

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Pētījuma mērķis bija noteikt jaunsintezētu multiheterociklisku savienojumu minimālo inhibējošo koncentrāciju (MIC), kā arī tai atbilstošo minimālo baktericīdo koncentrāciju (MBC) vai minimālo fungicīdo koncentrāciju (MFC). Izvērtējot iegūtos rezultātus, tālāk pārbaudīti aktīvākākie savienojumi, kuru MIC ≤64 mikrogrami/ml un MBC vai MFC ≤64 mikrogrami/ml. Ir apkopoti un analizēti literatūras avoti baktērijām, sēnēm un antimikrobiālām vielām. Darba gaitā izmantota agara difūzijas, MIC noteikšanas (un tai atbilstošā MBC vai MFC noteikšana) metode, kā arī agarozes gēla elektroforēze. Inhibitorās aktivitātes noteikšanā tika izmantota Escherichia coli DNS girāze. Pētījumā izmantotas piecas baktēriju un divas sēņu sugas, kas iegūtas no Latvijas Mikroorganismu kultūru kolekcijas, kā arī Latvijas Organiskās sintēzes institūtā sintezētie savienojumi (kopumā divdesmit astoņi).

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/26899

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
  - PE2_3Experimental particle physics with accelerators
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  - PE2_6Nuclear, hadron and heavy ion physics
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  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
  - PE2_11Ultra-cold atoms and molecules
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  - PE2_14Lasers, ultra-short lasers and laser physics
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  - PE2_16Non-linear physics
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LSLife Sciences
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SHSocial Sciences and Humanities
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