6533b85bfe1ef96bd12bbc67

RESEARCH PRODUCT

Rôle du cortex piriforme dans la mémoire olfactive: une étude comportementale et anatomo-fonctionnelle à l'aide de la détection immunohistochimique de la protéine Fos

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description

Because of its anatomical and functional features, the piriform cortex (PC) could play a crucial rolein olfactory learning and memory. We studied its implication in mnesic processes using theimmunodetection of Fos protein in rat. A water-rewarded olfactory discrimination task in a four-armsmaze was used for conditioning. We analysed Fos expression in PC as well as in neocortex andhippocampus, after completion of the discrimination task, at different time-points throughout learningand following its reactivation. In PC, we showed that Fos expression was different depending of thevelocity to learning of the conditioned rat. Furthermore, we confirmed the functional heterogeneity ofthe PC subdivisions and observed the implication of hippocampal and neocortical areas in the olfactorymemory processes.